Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.8K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

76.7K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
76.7K
What is Population Genetics?01:25

What is Population Genetics?

65.0K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.0K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

727
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
727
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

18.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unanswered Questions About Microscopic Hematuria With Tubulopathy.

Kidney international reports·2026
Same author

Social Disadvantage and Language Disorder: Is Dissociating Possible?

American journal of speech-language pathology·2026
Same author

A prevalence study of Autism Spectrum Disorder in Russia.

Frontiers in psychiatry·2026
Same author

Oxytocin dynamics and synchrony in mother-child dyads: Long-term neuroendocrine effects of maternal institutionalization.

Psychoneuroendocrinology·2026
Same author

Perceived Antisemitism and Mental Health in Jewish Mothers and Their Children.

Research on child and adolescent psychopathology·2026
Same author

Butyrate-Mediated Upregulation of Insulin Pathway Gene Expression Suggests Potential Antidiabetic Effects.

Drug development research·2025

Related Experiment Video

Updated: Feb 16, 2026

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals
07:40

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals

Published on: March 13, 2011

21.4K

Ancestry inference of 96 population samples using microhaplotypes.

Ozlem Bulbul1, Andrew J Pakstis2, Usha Soundararajan2

  • 1Institute of Forensic Science, Istanbul University, 34098, Istanbul, Turkey.

International Journal of Legal Medicine
|December 18, 2017
PubMed
Summary

Microhaplotypes, short DNA segments with multiple SNPs, are powerful forensic tools. New research expands their utility by analyzing allele frequencies in diverse populations for improved identification and mixture deconvolution.

Keywords:
AncestryForensicsMassively parallel sequencing (MPS)MicrohaplotypeSNP

More Related Videos

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

23.2K
Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.8K

Related Experiment Videos

Last Updated: Feb 16, 2026

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals
07:40

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals

Published on: March 13, 2011

21.4K
Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

23.2K
Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.8K

Area of Science:

  • Forensic genetics
  • Population genetics
  • Genomic sequencing

Background:

  • Microhaplotypes are novel forensic markers utilizing multi-SNP loci for direct haplotype determination via massively parallel sequencing (MPS).
  • Their short length (under 300 bp) is compatible with current MPS read lengths, enabling phased sequencing of individual chromosomes.
  • Previous studies published data on 130 microhaplotype loci across 83 populations.

Purpose of the Study:

  • To expand the understanding of global microhaplotype allele frequency variation.
  • To assess the utility of selected microhaplotype loci for distinguishing populations across biogeographic regions.

Main Methods:

  • Genotyping of 13 additional populations using 65 microhaplotype loci, including 8 novel loci.
  • Analysis focused on loci exhibiting high inter-population gene frequency variation.
  • Massively parallel sequencing (MPS) was employed for allele determination.

Main Results:

  • The tested microhaplotype loci demonstrated clear distinctions among 6 major biogeographic regions.
  • These loci provided valuable information for differentiating up to 10 distinct population clusters.
  • Allele frequency data was expanded for a broader global representation.

Conclusions:

  • Microhaplotypes are effective tools for forensic identification and mixture analysis.
  • Expanded population data enhances the discriminatory power of microhaplotypes globally.
  • These markers show significant potential for resolving population structure and biogeographic origins.