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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Overview
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Articles linked to this work by shared authors, journal, and citation graph.

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[Aerobiological study of anemophilous pollens in the city of Toluca, Mexico].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)·2015
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Updated: Feb 16, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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[Severe atopic dermatitis and hiper-IgE].

María Luz Cid Del Prado-Izquierdo1, Osvaldo Zarco-Cid Del Prado, Ángel Visoso-Salgado

  • 1Médica Bosques, Clínica de Asma, Alergia e Inmunología, Toluca, Estado de México, México. lucy_14delprado@hotmail.com.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|December 18, 2017
PubMed
Summary

This study presents a severe case of atopic dermatitis (AD) in a young male. A combination therapy including methotrexate and tacrolimus proved highly effective after initial treatments failed.

Keywords:
Atopic dermatitisChronic inflammatory skin diseaseImmunoglobulin E

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Atopic dermatitis (AD) is a chronic, inflammatory skin condition affecting 5-15% of the general population.
  • Characterized by itchy, dry skin and recurring flare-ups, AD often has a familial link to atopy.

Observation:

  • A 19-year-old male presented with severe AD (SCORAD 84.3) and significantly elevated IgE levels (34,400 UI/mL).
  • Initial treatment with deflazacort, healing creams, emollients, and a detergent-free gel yielded unsatisfactory results.

Findings:

  • A combined therapeutic approach involving deflazacort, methotrexate, tacrolimus, and transfer factor was initiated.
  • This intensive treatment regimen resulted in excellent clinical improvement for the patient.

Implications:

  • The case highlights the potential of combination therapy for managing severe, refractory atopic dermatitis.
  • Disease evolution and individualized treatment strategies are crucial for optimizing patient outcomes in AD management.