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Updated: Feb 16, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Recent advances in the synthesis of cyclic pseudopeptides
Serge Zaretsky1, Andrei K Yudin1
1University of Toronto, Lash Miller Chemical Labs, 80 St. George Street, Toronto, ON M5S 3H6, Canada.
Abstract:
Constrained peptides pose tremendous value in drug discovery. For example, owing to their large surface areas, they offer novel ways at inhibiting protein-protein interactions. As this field has grown, it has become desirable to introduce non-peptidic functionality into these rings to enable differentiated structure activity relationships and improved pharmacokinetic properties. Recent advances in the synthesis of cyclic pseudopeptides include macrocyclization through cysteine alkylation, multicomponent reactions, decarboxylative couplings, and novel stapling chemistry.
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