Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Symbiosis

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A pooled CRISPR screen reveals genes critical for erythroblast enucleation.

bioRxiv : the preprint server for biology·2026

Same author

CD44 cross-linking promotes Plasmodium falciparum invasion.

Nature communications·2025

Same author

<i>Plasmodium falciparum</i> exploits NUAK1 to establish infection in human erythrocytes.

bioRxiv : the preprint server for biology·2025

Same author

CD44 cross-linking promotes <i>Plasmodium falciparum</i> invasion.

bioRxiv : the preprint server for biology·2025

Same author

Cryogenic electron tomography reveals novel structures in the apical complex of <i>Plasmodium falciparum</i>.

mBio·2024

Same author

Plasmodium falciparum exploits CD44 as a coreceptor for erythrocyte invasion.

Blood·2023

Search research articles

Related Experiment Video

Updated: Feb 16, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Beyond Hemoglobin: Screening for Malaria Host Factors.

Elizabeth S Egan¹

¹Stanford University School of Medicine, 300 Pasteur Drive Room G312 Stanford, CA 94305, USA.

Trends in Genetics : TIG

|December 19, 2017

Summary

This summary is machine-generated.

Severe malaria, caused by Plasmodium falciparum, poses a global health threat. Hematopoietic stem cell technology offers a new genetic approach to identify erythrocyte factors influencing malaria infection, improving host-pathogen interaction understanding.

More Related Videos

A Multi-detection Assay for Malaria Transmitting Mosquitoes

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Published on: May 30, 2019

Related Experiment Videos

Last Updated: Feb 16, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

A Multi-detection Assay for Malaria Transmitting Mosquitoes

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Published on: May 30, 2019

Area of Science:

Parasitology
Genetics
Hematology

Background:

Severe malaria, caused by Plasmodium falciparum, leads to significant global mortality, especially in vulnerable populations.
Plasmodium falciparum infects human erythrocytes, and natural variations in these cells can confer protection against severe malaria.
Genetic studies of erythrocyte determinants of malaria are challenging due to the enucleated nature of mature erythrocytes.

Purpose of the Study:

To review recent advancements in using hematopoietic stem cells for genetic screening of malaria host factors.
To explore the potential of hematopoietic stem cell-based approaches in understanding host-pathogen interactions in malaria.

Main Methods:

Utilizing hematopoietic stem cells to enable genetic screening for erythrocyte-related malaria host factors.
Reviewing recent scientific literature on genetic approaches to malaria host-pathogen interactions.

Main Results:

Hematopoietic stem cell technology facilitates genetic screening for malaria host factors.
This approach offers a promising avenue for discovering novel erythrocyte determinants of malaria susceptibility.

Conclusions:

Despite existing challenges, hematopoietic stem cell-based genetic screening is a valuable tool for advancing malaria research.
This methodology holds significant promise for uncovering new insights into Plasmodium falciparum-erythrocyte interactions and developing targeted interventions.