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Related Concept Videos

Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
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Therapeutic Drug Monitoring: Overview and Classification01:16

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
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Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
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Therapeutic Drug Monitoring: Affecting Factors01:29

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Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
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Updated: Feb 16, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
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An automated dose tracking system for adaptive radiation therapy.

Chang Liu1, Jinkoo Kim2, Akila Kumarasiri1

  • 1Department of Radiation Oncology, Josephine Ford Cancer Institute, Henry Ford Health System, Detroit, MI, USA.

Computer Methods and Programs in Biomedicine
|December 19, 2017
PubMed
Summary

An automated dose tracking system streamlines adaptive radiation therapy (ART) by significantly reducing manual effort and computation time. This innovation facilitates the routine clinical application of ART for enhanced radiation therapy effectiveness.

Keywords:
Adaptive radiation therapyDose trackingSoftware

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Clinical Engineering

Background:

  • Implementing adaptive radiation therapy (ART) in clinical practice presents significant technical and resource challenges.
  • Validating each step of the ART process is crucial for its successful integration.

Purpose of the Study:

  • To identify key components of adaptive radiation therapy (ART).
  • To demonstrate how an automated procedure enhances ART efficiency.
  • To promote the routine clinical use of ART.

Main Methods:

  • Developed in-house software with modular components (ART engine, user tools, integration tools) for automated dose tracking.
  • Utilized C++ and C# for independent program modules within a distributed Windows environment.
  • Integrated custom GUIs for user interaction, including deformable image registration (DIR), and a scripting API for automated dose calculation.

Main Results:

  • Retrospectively evaluated on 20 prostate and 96 head and neck cancer patients; prospectively on 4 head and neck cancer patients.
  • Processed 780 prostate and 2586 head and neck cancer dose fractions, including DIR and dose mapping.
  • Achieved average daily cumulative dose computation in 3 hours with only 13 minutes of manual work per case.

Conclusions:

  • Presented an efficient and user-friendly dose tracking system for clinical adaptive radiation therapy (ART).
  • The automated software and processes were rigorously validated using patient data.
  • Automation significantly improved efficiency, enabling routine clinical application of ART to enhance treatment outcomes.