Related Experiment Video
Updated: Feb 16, 2026
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
[Stained amniotic fluid and meconium amniotic fluid: Should they change our obstetric management ?]
A de Souza1, H Minebois1, A Luc2
1Pôle d'obstétrique et de médecine fœtale, maternité régionale universitaire, CHRU de Nancy, 10, rue du Dr-Heydenreich, 54000 Nancy, France; Université de Lorraine, 34, cour Léopold, 54000 Nancy, France.
Objectives:
To assess if a stained or meconial amniotic fluid during labor is correlated with a greater risk of neonatal metabolic acidosis.
Methods:
In a retrospective case-control study carried out in a level 3 maternity from 1st of January to 31st of December 2014, all patients who delivered a singleton eutrophic fetus in cephalic presentation after 37WG and with a stained or meconial amniotic fluid during labor were included. Obstetrical and neonatal outcomes were compared according to the amniotic fluid's color.
Results:
At all, 302 patients in the group « Abnormal amniotic fluid» (198 patients with stained amniotic fluid, 104 with meconial amniotic fluid) vs. 302 in the group « clear amniotic fluid» were included. No significant difference on the rate of neonatal severe acidosis between the two groups were found. Fetal heart rhythm abnormalities were more frequent in case of meconial amniotic fluid (11,3% vs. 31,7%, P<0,0001). The composite endpoint, defined by the association of umbilical arterial pH <7,0±base excess ≥12mmol/L±Apgar score at 5min <7, was more frequent in case of meconial amniotic fluid (4,0% vs. 12,5%, P=0,0018).
Conclusion:
The occurrence of severe neonatal metabolic acidosis was not more frequent in case of stained or meconial amniotic fluid, but with an increase in the use of fetal scalp pH and cesaerian deliveries when the fluid was meconial.
