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Lithium Suppresses Hedgehog Signaling via Promoting ITCH E3 Ligase Activity and Gli1-SUFU Interaction in PDA Cells

Xinshuo Wang1,2, Zijian Fang1, Anlin Wang1

  • 1State Key Laboratory of Natural Medicines, School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China.

Frontiers in Pharmacology
|December 19, 2017
PubMed

Keywords:
GSK3βGli1ITCHhedgehog signalinglithiumpancreatic cancerubiquitination

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