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Liver X receptors as potential targets for cancer therapeutics

Xiaoli Ju1, Pan Huang1, Miao Chen1,2

  • 1Department of Pathology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

Oncology Letters
|December 19, 2017
PubMed

Insights

Liver X receptors (LXRs) regulate cholesterol and immunity. Emerging research suggests LXRs are promising therapeutic targets for various cancers, offering new avenues for clinical treatment.

Area of Science:

  • Molecular biology
  • Endocrinology
  • Oncology

Background:

  • Liver X receptors (LXRs) are nuclear receptors involved in cholesterol transport and immune responses.
  • Synthetic LXR ligands are utilized for treating metabolic and cardiovascular diseases.
  • Emerging evidence implicates LXRs in the pathogenesis of various cancers.

Purpose of the Study:

  • To review current knowledge on LXR ligands and their mechanisms.
  • To summarize the role of LXRs in different cancer types.
  • To evaluate the potential of LXRs as cancer therapeutic targets.

Main Methods:

  • Literature review of studies on LXR ligands and their effects in cancer.
  • Analysis of the mechanisms of action of LXRs in cancer.
  • Synthesis of data on clinical applications of LXR-targeting therapies.

Main Results:

  • LXR ligands exhibit diverse mechanisms of action.
  • LXRs play significant roles in the development and progression of multiple cancer types.
  • Preclinical data suggest potential for LXR-based cancer treatments.

Conclusions:

  • LXRs are implicated in cancer and represent potential therapeutic targets.
  • Further research into LXR modulation could lead to novel cancer therapies.
  • Clinical translation of LXR-targeting strategies warrants investigation.
Keywords:
cancercancer therapeuticsclinical applicationliver X receptors

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