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Updated: Feb 16, 2026

Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes
Published on: November 21, 2017
Nickel-catalyzed amination of aryl fluorides with primary amines
Tomoya Harada1, Yusuke Ueda, Tomohiro Iwai
1Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. iwai-t@sci.hokudai.ac.jp sawamura@sci.hokudai.ac.jp.
Abstract:
The Ni-catalyzed cross-coupling reaction between aryl fluorides and primary amines was enabled by the 1,2-bis(dicyclohexylphosphino)benzene (DCYPBz) or 1,2-bis(dicyclohexylphosphino)ethane (DCYPE) ligands. Both N-alkyl- and N-aryl-substituted primary amines participated in the selective reaction to form secondary amines. This protocol would potentially be useful for late-stage diversification of fluorinated compounds with complex structures for the synthesis of functionally interesting aniline derivatives.
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