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Anatomic variants in Dandy-Walker complex.

Maria Claudia Jurcă1, Kinga Kozma, CodruŢa Diana Petcheşi

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Dandy-Walker complex (DWC) is a group of central nervous system malformations. Diagnosis relies on clinical and imaging data, with varied presentations requiring tailored management.

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Area of Science:

  • Neurology
  • Developmental Biology
  • Medical Imaging

Background:

  • Dandy-Walker complex (DWC) encompasses diverse central nervous system malformations.
  • Includes Dandy-Walker malformation, Dandy-Walker variant, mega cisterna magna, and posterior fossa arachnoid cyst.
  • Characterized by posterior fossa abnormalities and variable vermian and fourth ventricle involvement.

Observation:

  • Presents four cases illustrating the morphological and clinical spectrum of DWC.
  • Diagnosis integrated clinical signs (macrocephaly, seizures) with imaging (X-ray, CT, MRI).
  • Observed diverse presentations including rare associations like neurofibromatosis and congenital anomalies.

Findings:

  • Two cases diagnosed with Dandy-Walker complex.
  • One case of Dandy-Walker variant associated with neurofibromatosis.
  • One case of posterior fossa arachnoid cyst with Horner's syndrome and cardiac defects.

Implications:

  • Highlights the variability in clinical, radiological, and functional manifestations of DWC.
  • Emphasizes the need for comprehensive diagnostic approaches.
  • Underscores the requirement for individualized therapeutic strategies for DWC patients.