Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemical Characterization of Volatile Terpenoids in Teucrium polium L. Essential Oil Evaluated by GC-MS/FID and Its Associated Biological Properties.

Chemistry & biodiversity·2026
Same author

Comment on "Diagnostic Guidance for Chronic Complex Regional Pain Syndrome Type I and Type II from The American Society of Interventional Physicians (ASIPP)".

Pain physician·2026
Same author

Defining "regional" pain.

Pain·2026
Same author

Impact of fibromyalgia syndrome diagnosis and treatment experiences on health information-seeking behaviour: A cross-sectional online survey.

British journal of pain·2026
Same author

A Protocol for Characterizing Comprehensive Two-Dimensional Liquid Chromatography Systems.

Journal of separation science·2026
Same author

QSRR-based insights into the chromatographic behaviour of phenolic derivatives on biomimetic stationary phases.

Journal of chromatography. A·2026

Related Experiment Video

Updated: Feb 16, 2026

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
11:22

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

Published on: April 29, 2013

13.8K

A technique to assess perineuronal mediators.

Andreas Goebel1, Maggie Kitman Lee2, Francesco Cacciola2

  • 1a Pain Research Institute, Translational Medicine, University of Liverpool , Liverpool , UK.

British Journal of Neurosurgery
|December 19, 2017
PubMed
Summary

Researchers developed a new method to measure inflammatory mediators near human sensory nerves. This technique revealed changes in mediator levels in patients with trigeminal neuralgia, offering insights into chronic pain mechanisms.

Keywords:
Assessing mediator profilesChronic painPerineural mediatorsTrigeminal neuralgia

More Related Videos

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

10.1K
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

5.7K

Related Experiment Videos

Last Updated: Feb 16, 2026

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
11:22

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

Published on: April 29, 2013

13.8K
Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

10.1K
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

5.7K

Area of Science:

  • Neuroscience
  • Immunology
  • Pain Research

Background:

  • Inflammatory mediators, such as interleukin 1 beta (IL-1β), activate peripheral nerves, contributing to pain perception.
  • IL-1β binding to neuronal receptors (IL-1R1) increases neuronal sensitivity to heat, exacerbating pain signaling.
  • Understanding these inflammatory processes is vital for investigating the role of inflammation in chronic pain conditions.

Purpose of the Study:

  • To introduce a novel in vivo method for assessing inflammatory mediator profiles around human sensory nerve roots.
  • To investigate the potential of this method in understanding the pathophysiology of trigeminal neuralgia.

Main Methods:

  • A new methodology was developed to assess mediator profiles in the human trigeminal system, specifically where the nerve root exits the brain stem.
  • Samples were collected from different locations on the trigeminal nerve root in patients.

Main Results:

  • The study demonstrated that mediator levels varied across different sample locations on the trigeminal nerve root.
  • These changes were observed in patients diagnosed with trigeminal neuralgia.

Conclusions:

  • The novel methodology allows for the assessment of mediator profiles in the human trigeminal nerve root in vivo.
  • Findings suggest this approach can provide insights into the pathophysiology of trigeminal neuralgia, potentially guiding clinical treatment decisions.