Related Experiment Video
Updated: Feb 16, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Use of Uncrossmatched Erythrocytes in Emergency Bleeding Situations
Mark H Yazer1, Jonathan H Waters, Philip C Spinella
1From the Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania (M.H.Y.); the Department of Anesthesiology, University of Pittsburgh, Pennsylvania (J.H.W.); and the Department of Pediatrics, Division of Critical Care Medicine, Washington University in St. Louis, St. Louis, Missouri (P.C.S.). U.S. Army Institute of Surgical Research, San Antonio, Texas U.S. Armed Services Blood Program, Washington, DC AABB, Bethesda, Maryland Department of Surgery, Division of Trauma and Emergency Surgery, University of Texas San Antonio, San Antonio, Texas AABB, Bethesda, Maryland Department of Surgery, University of Colorado, Denver, Colorado Johns Hopkins University School of Medicine, Baltimore, Maryland Magen David Adom National Blood Services, Ramat Gan, Israel Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota Department of Emergency Medicine, Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, Michigan.
No abstract available in PubMed .
Related Concept Videos
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythropoiesis
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

