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Visualizing Visual Adaptation
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Three Cardinal Lessons from ADAPT - 10 Years on.

J C S Breitner1, C G Lyketsos

  • 1Dr. Breitner, Centre for Studies on Prevention of Alzheimer's Disease, Douglas Hospital Research Centre; Faculty of Medicine, McGill University, john.breitner@mcgill.ca.

The Journal of Prevention of Alzheimer'S Disease
|December 19, 2017
PubMed
Summary
This summary is machine-generated.

The Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT) investigated NSAIDs for Alzheimer's disease (AD) prevention but faced complications. Ultimately, the trial yielded null results due to design and execution issues.

Keywords:
Alzheimer’s diseasecelecoxibnaproxenpreventionrandomized controlled trial

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Trials

Background:

  • Alzheimer's disease (AD) poses a significant public health challenge.
  • Pharmaco-prevention strategies, including non-steroidal anti-inflammatory drugs (NSAIDs), have been explored for AD.
  • Previous research suggested potential benefits of NSAIDs in AD prevention.

Purpose of the Study:

  • To evaluate the efficacy of naproxen sodium and celecoxib in preventing incident Alzheimer's disease dementia.
  • To assess the safety and tolerability of these NSAIDs in older adults at increased risk for AD.
  • To analyze the complexities and challenges encountered during the trial's execution.

Main Methods:

  • A placebo-controlled, three-arm pharmaco-prevention trial design.
  • Inclusion of older adults (70+) with a first-degree family history of AD but cognitively healthy at enrollment.
  • Administration of naproxen sodium and celecoxib for an average of two years.

Main Results:

  • The trial encountered significant complications leading to early termination of treatments.
  • Interim results were complex and did not yield conclusive findings.
  • The final analysis of the Alzheimer's Disease Anti-inflammatory Prevention Trial demonstrated null results for AD prevention.

Conclusions:

  • The ADAPT trial was terminated prematurely due to various complications.
  • The trial's design and execution issues hindered the ability to obtain conclusive results.
  • Preliminary data should guide future ambitious Phase III trials for better outcomes and cost-effectiveness.