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Modelling of plasma-separation through microporous membranes.
B B Gupta1, M Y Jaffrin, L H Ding
1Department of Biological Engineering, University of Technology of Compiegne, France.
The International Journal of Artificial Organs
|January 1, 1989
Summary
Mathematical models accurately predict plasma filtration rates in ultrafiltration, especially with pulsating flow. This study enhances understanding of filtration velocity and hemolysis limits in hollow-fiber filters during plasmapheresis.
Area of Science:
- Biomedical Engineering
- Fluid Dynamics
- Hemodynamics
Background:
- Mathematical models are used to predict plasma filtration rates in ultrafiltration.
- Understanding these rates is crucial for optimizing medical procedures like plasmapheresis.
Purpose of the Study:
- To compare predicted and experimentally obtained filtration rates using hollow-fiber filters.
- To investigate the effect of pulsatile flow on plasma filtration rate.
- To present relationships between plasma filtration velocity, hemolysis limit, wall shear rate, and filter size.
Main Methods:
- In vitro plasmapheresis experiments using hollow-fiber filters (500-1000 cm2) with bovine blood.
- Comparison of experimental data with models based on concentration polarization and lift velocity theories.
- Evaluation of ultrafiltration models incorporating pulsating flow.
Main Results:
- Models based on concentration polarization and lift velocity theories showed good agreement with experimental filtration rates.
- Pulsatile inlet flow increased plasma filtration rate by 20-50% compared to non-pulsatile conditions.
- Results align with a modified ultrafiltration model for pulsating flow.
Conclusions:
- Validated mathematical models for predicting plasma filtration rates in ultrafiltration.
- Demonstrated the significant impact of pulsatile flow on filtration efficiency.
- Provided key relationships for optimizing filter design and performance in plasmapheresis, considering hemolysis limits.