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Updated: Aug 3, 2026

A Simple Critical-sized Femoral Defect Model in Mice
Published on: March 15, 2015
Atypical Vancouver Type-C Periprosthetic Fracture Complicated by Nonunion: A Case Report
Foster Chen1, Robert Li, Ajay Lall
1Department of Orthopaedic Surgery, Montefiore Medical Center, 1250 Waters Place, 11th Floor, Bronx, NY 10461. foster.chen.med@gmail.com.
Case:
In recent years, atypical femoral fractures (AFFs) associated with bisphosphonate use have increasingly been reported, but current definitions limit their diagnosis to native femora. Atypical periprosthetic fractures are rare. We present a case of a Vancouver type-C periprosthetic fracture that was recognized as an AFF following nonunion.
Conclusion:
Bisphosphonate-associated AFFs can present as periprosthetic fractures. Delayed recognition of the role of bisphosphonates in a periprosthetic fracture may lead to a worse outcome, including a delay in diagnosis, delayed union, and failure of fixation.

