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Updated: Feb 16, 2026

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
PARACENTRAL ACUTE MIDDLE MACULOPATHY IN PREGNANCY
Xuejing Chen1,2, Shilpa J Desai1,2, Caroline R Baumal1
1Retina Department, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Boston, Massachusetts; and.
Purpose:
To describe a case of paracentral acute middle maculopathy (PAMM) during the first trimester of pregnancy without other ocular or systemic comorbidities.
Methods:
Case report.
Results:
A 31-year-old woman in her first trimester of pregnancy presented with a paracentral scotoma in the absence of other retinal pathology or systemic associations. Optical coherence tomography showed a classic acute PAMM lesion, and optical coherence tomography angiography showed preservation of vascular flow in the area of the PAMM lesion 1 week after symptom onset. Subsequent workup for underlying systemic disease that can affect the retinal vasculature was negative.
Conclusion:
Paracentral acute middle maculopathy lesions have been described in eyes with retinal vascular disease and in people with systemic vascular diseases or events. This is the first described case of a PAMM lesion in the absence of associated factors other than an uncomplicated pregnancy.
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