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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Feb 16, 2026

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
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Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

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Informatics for cancer immunotherapy.

J Hammerbacher1,2, A Snyder3,4

  • 1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|December 19, 2017
PubMed
Summary
This summary is machine-generated.

Cancer immunotherapies are advancing rapidly. This review explores informatics methods for analyzing tumor genetics, immunity, and their integration for developing novel cancer vaccines and therapies.

Keywords:
adoptive cell transferbioinformaticscheckpoint blockadecomputational biologyimmunotherapyneoantigens

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Area of Science:

  • Computational biology and bioinformatics
  • Cancer immunology and immunotherapy
  • Genomic and transcriptomic analysis

Background:

  • The rise of immunomodulatory cancer therapies necessitates advanced analytical approaches.
  • Understanding the tumor and its microenvironment is crucial for effective treatment.
  • Systemic immunity measures provide insights into patient response to therapy.

Purpose of the Study:

  • To review the application of informatics techniques in cancer immunotherapy research.
  • To explore methods for analyzing tumor genetic and expression data.
  • To discuss the integration of diverse immunological data for therapy development.

Main Methods:

  • Analysis of genetic and expression data from tumors.
  • Assessment of tumor immunity using HLA status, neoantigen prediction, and immune deconvolution.
  • T-cell receptor sequencing for immune repertoire analysis.

Main Results:

  • Informatics strategies are increasingly used to analyze tumor and immune characteristics.
  • Current methods allow for detailed assessment of the tumor immune microenvironment.
  • Data integration approaches are emerging but still in early development stages.

Conclusions:

  • Informatics plays a vital role in advancing cancer immunotherapy.
  • Integration of multi-omics data holds promise for personalized cancer treatment.
  • Future directions include refining informatics tools for vaccine, adoptive cell transfer, and checkpoint blockade therapies.