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Management of Zika virus in pregnancy: a review
Helen Perry1,2, Asma Khalil1,2, Emma Aarons3
1Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Introduction/Background:
Since 2015, an epidemic of Zika virus spread across the Americas. This coincided with an increased incidence of microcephaly reported at birth in Brazil, with subsequent evidence of a causal association.
Sources Of Data:
Systemic reviews, observational studies, public health organizations.
Areas Of Agreement:
Zika virus causes microcephaly and brain abnormalities in infants born to mothers infected during or shortly before pregnancy. Zika virus is a trigger for Guillain Barre Syndrome. Whilst mosquito bite is the main route of transmission, sexual transmission is another confirmed route.
Areas Of Controversy:
Uncertainty remains regarding the proportion of Zika-infected pregnancies that will give rise to a significantly affected infant.
Growing Points:
The development of a vaccine remains a priority whilst public health efforts continue to educate at risk populations on reducing transmission.
Areas Timely For Developing Research:
Follow-up studies of affected infants are vital to inform on prognosis and guide screening programmes of the future.
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