Nonhuman Primates and Translational Research: Progress, Opportunities, and Challenges.

Area of Science:

• Translational research
• Comparative medicine
• Biomedical science

Background:

• Nonhuman primates (NHPs) are genetically, physiologically, and behaviorally similar to humans.
• NHPs serve as critical animal models in translational research for human disease interventions.
• Results from NHP studies are often the final criterion before human clinical trials.

Purpose of the Study:

• To review the application of NHP models in studying prevalent and burdensome human diseases.
• To consolidate information on NHP models for diverse research areas, including infectious diseases, neurodegenerative disorders, and metabolic diseases.
• To highlight the importance of proper NHP husbandry and environmental enrichment for research validity.

Main Methods:

• Compilation of articles discussing NHP models for various human diseases.
• Inclusion of reviews on NHP husbandry and environmental enrichment procedures.
• Analysis of successes, limitations, challenges, and opportunities in NHP translational research.

Main Results:

• NHP models are vital for studying a wide range of human diseases, including tuberculosis, viral hepatitis, HIV/AIDS, neurodegenerative disorders, and cardiovascular disease.
• Proper animal husbandry and environmental enrichment are critical for maintaining NHP health and ensuring reliable research outcomes.
• The collection provides a comprehensive overview of NHP applications in translational research.

Conclusions:

• NHP models are indispensable for advancing human health by facilitating the development of new therapeutics and vaccines.
• Effective NHP model utilization requires careful consideration of research-specific needs and ethical husbandry practices.
• Continued research and collaboration are essential to overcome challenges and maximize opportunities in NHP-based translational studies.