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Published on: July 6, 2013
Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1)
Aayushi Uberoi1, Satoshi Yoshida1, Paul F Lambert1
1McArdle Laboratory of Cancer Research, 1111 Highland Avenue, University of Wisconsin, Madison 53705, United States.
Abstract:
Preclinical model systems to study multiple features of the papillomavirus life cycle are extremely valuable tools to aid our understanding of Human Papillomavirus (HPV) biology, disease progression and treatments. Mouse papillomavirus (MmuPV1) is the first ever rodent papillomavirus that can infect the laboratory strain of mice and was discovered recently in 2011. This model is an attractive model to study papillomavirus pathogenesis due to the ubiquitous availability of lab mice and the fact that this mouse species is easily genetically modifiable. Several other groups, including ours, have reported that MmuPV1-induced papillomas are restricted to T-cell deficient immunosuppressed mice. In our lab we showed for the first time that MmuPV1 causes skin cancers in UVB-irradiated immunocompetent animals. In this report we describe in detail the MmuPV1-UV infection model that can be adapted to study MmuPV1 biology in immunocompetent animals.
Insights
A novel mouse model using mouse papillomavirus (MmuPV1) and UVB irradiation enables the study of Human Papillomavirus (HPV) in immunocompetent animals, advancing research into HPV pathogenesis and skin cancer development.
Area of Science:
- Virology
- Immunology
- Dermatology
Background:
- Preclinical models are crucial for understanding Human Papillomavirus (HPV) biology and disease.
- Mouse papillomavirus (MmuPV1), discovered in 2011, offers a promising model due to mouse genetic tractability.
- Previous studies indicated MmuPV1-induced papillomas occur only in immunosuppressed mice.
Purpose of the Study:
- To detail a novel MmuPV1-UV infection model.
- To facilitate the study of MmuPV1 biology in immunocompetent animal models.
- To explore papillomavirus pathogenesis in a broader context.
Main Methods:
- Infection of laboratory mice with Mouse Papillomavirus (MmuPV1).
- Exposure of infected mice to Ultraviolet B (UVB) irradiation.
- Observation and analysis of MmuPV1-induced skin lesions and cancers in immunocompetent mice.
Main Results:
- Mouse papillomavirus (MmuPV1) infection combined with UVB irradiation induced skin cancers in immunocompetent mice.
- This demonstrates a new capacity for MmuPV1 to cause disease in a non-immunosuppressed host.
- The MmuPV1-UV model provides a platform for studying papillomavirus-induced skin carcinogenesis.
Conclusions:
- The MmuPV1-UV model is effective for studying papillomavirus infection and pathogenesis in immunocompetent animals.
- This model system advances the understanding of HPV-related skin cancer development.
- Further research utilizing this model can aid in developing new therapeutic strategies for HPV-associated diseases.
