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Association between single nucleotide polymorphisms in TLR4, TLR2, TLR9, VDR, NOS2 and CCL5 genes with acute viral

Alfonso Eduardo Alvarez1, Fernando Augusto Lima Marson2, Carmen Sílvia Bertuzzo3

  • 1Department of Pediatrics, Faculty of Medical Sciences, University of Campinas, Rua Tessália Vieira de Camargo, 126, Cidade Universitária Zeferino Vaz, Campinas CEP 13083-887, São Paulo, Brazil.

Gene
|December 19, 2017
PubMed

Insights

Genetic variations in immune response genes are linked to infant bronchiolitis risk and severity. Specific single nucleotide polymorphisms (SNPs) in CCL5 and NOS2 correlate with bronchiolitis, while others in TLR4, TLR2, TLR9, VDR, and CCL5 indicate disease severity.

Area of Science:

  • Pediatric Infectious Diseases
  • Immunogenetics
  • Respiratory Medicine

Background:

  • Acute viral bronchiolitis is a primary cause of infant hospitalization.
  • Most affected infants are otherwise healthy and lack identifiable risk factors.
  • Understanding genetic predispositions is crucial for managing bronchiolitis.

Purpose of the Study:

  • To identify genetic features associated with the risk of developing bronchiolitis.
  • To determine genetic factors linked to the severity of bronchiolitis in infants.

Main Methods:

  • Prospective evaluation of 181 infants with severe bronchiolitis requiring oxygen therapy.
  • Control group comprised 536 healthy adults.
  • Analysis included comorbidities, viral detection via multiplex-PCR, and identification of single nucleotide polymorphisms (SNPs) in immune response genes.

Main Results:

  • SNP rs2107538*CCL5 associated with respiratory syncytial virus (RSV) bronchiolitis.
  • SNP rs1060826*NOS2 linked to rhinovirus-induced bronchiolitis.
  • SNPs in TLR4, TLR2, TLR9, VDR, and CCL5 correlated with severe outcomes like death, ICU admission, and need for mechanical ventilation.

Conclusions:

  • SNPs in CCL5 and NOS2 are associated with bronchiolitis presence.
  • SNPs in TLR4, TLR2, TLR9, VDR, and CCL5 are linked to bronchiolitis severity.
  • Genetic analysis offers insights into bronchiolitis risk and progression.
Abstract

Keywords:
GeneticsInfantsRespiratory syncytial virusRisk factorsToll-like receptors

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