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Disease tolerance: concept and mechanisms.

J L McCarville¹, J S Ayres¹

¹Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Current Opinion in Immunology

|December 19, 2017

Summary

Host survival involves resistance (killing pathogens) and tolerance (maintaining health despite pathogens). This review explores how disease tolerance, beyond pathogen resistance, impacts immune regulation, tissue damage, and T cell function.

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Area of Science:

Immunology
Infectious Disease Biology
Host-Pathogen Interactions

Background:

Hosts employ resistance and tolerance for infectious disease survival.
Resistance aims to eliminate pathogens, while tolerance maintains host health.
Immune responses are traditionally viewed through the lens of resistance.

Purpose of the Study:

To integrate the concept of disease tolerance into current immunological studies.
To re-evaluate immune system functions beyond pathogen destruction.
To explore the role of tolerance in tissue damage, T cell exhaustion, and immune tolerance to antigens.

Main Methods:

Literature review and synthesis of recent immunological research.
Analysis of studies on innate and adaptive immune mechanisms.
Examination of immune regulation, tissue damage resolution, T cell exhaustion, and antigen tolerance.

Main Results:

Evidence suggests immune mechanisms have roles not explained by pathogen destruction alone.
Disease tolerance offers a complementary framework for understanding host-pathogen dynamics.
Tolerance influences tissue repair, T cell regulation, and immune responses to non-harmful substances.

Conclusions:

Rethinking immunity to include disease tolerance provides a more comprehensive understanding of host survival.
Tolerance mechanisms are crucial for managing infection and maintaining homeostasis.
Further research into tolerance is vital for developing novel therapeutic strategies.