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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
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Sugar-based gene delivery systems: Current knowledge and new perspectives.

Seo Jin Hong1, Min Hye Ahn1, Jaiprakash Sangshetti2

  • 1Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul, Republic of Korea.

Carbohydrate Polymers
|December 20, 2017
PubMed
Summary
This summary is machine-generated.

Polysaccharides offer biocompatible, cost-effective nanoparticles for nanomedicine. These carbohydrate-based polymers show great potential as non-viral gene delivery vectors for disease treatment.

Keywords:
CytotoxicityDrug/Gene deliveryNanocarriersNanomedicinePolysaccharidesTransfection efficiency

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Carbohydrates are abundant natural compounds vital in biological processes, with significant medical and industrial relevance.
  • Polysaccharides, a class of carbohydrates, possess inherent biocompatibility, targeting capabilities, and physicochemical properties suitable for biomedical applications.
  • Compared to synthetic polymers, polysaccharides offer advantages like low toxicity and cost-effectiveness.

Purpose of the Study:

  • To review the current state of polysaccharide-based polymers as non-viral gene delivery vectors.
  • To explore the potential of these carbohydrate-based nanoparticles in treating various diseases.
  • To discuss chemical modifications and structure-property relationships of polysaccharides for nanomedicine.

Main Methods:

  • Literature review focusing on polysaccharide-based nanoparticles for gene delivery.
  • Analysis of physicochemical properties, including biocompatibility, surface charge, and toxicity.
  • Examination of chemical modification strategies and their impact on nanoparticle characteristics.

Main Results:

  • Polysaccharide-based nanoparticles exhibit excellent biocompatibility and suitable surface charge for nucleic acid interaction.
  • These nanoparticles demonstrate low toxicity and cost-effectiveness, making them superior carriers in nanomedicine.
  • Chemical modification of polysaccharides allows for the preparation of a wide range of nanoparticles with tailored properties.

Conclusions:

  • Polysaccharides are promising biomaterials for developing effective non-viral gene delivery systems.
  • The inherent properties and chemical modifiability of polysaccharides enable their application in advanced nanomedicine.
  • Further research into structure-property relationships will optimize polysaccharide-based vectors for therapeutic applications.