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Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

863

KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression

Yuji Fujita1,2, Kiyoshi Masuda1, Junichi Hamada1,2

  • 1Department of Human Genetics, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.

Oncotarget
|December 20, 2017
PubMed

Insights

KH-type splicing regulatory protein (KHSRP) promotes esophageal squamous cell carcinoma (ESCC) by affecting microRNA maturation. Elevated KHSRP indicates poor prognosis and suggests it as a potential therapeutic target for ESCC.

Area of Science:

  • Molecular Biology
  • Oncology
  • RNA Metabolism

Background:

  • KH-type splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein involved in post-transcriptional RNA metabolism, including microRNA (miRNA) biogenesis.
  • KHSRP influences various cellular functions and pathological conditions.

Purpose of the Study:

  • To investigate the oncogenic functions of KHSRP and its mechanisms in esophageal squamous cell carcinoma (ESCC) pathogenesis.

Main Methods:

  • Immunohistochemistry to assess KHSRP expression in ESCC tumors versus non-tumorous tissues.
  • KHSRP knockdown experiments in ESCC cells.
  • Analysis of miRNA maturation and target mRNA expression.

Main Results:

  • KHSRP expression was elevated in ESCC tumors and correlated with worse overall survival.
  • KHSRP knockdown inhibited ESCC cell growth, migration, and invasion.
  • KHSRP knockdown impaired cancer-associated miRNA maturation and suppressed epithelial-to-mesenchymal transition.

Conclusions:

  • KHSRP exhibits oncogenic functions in esophageal tumorigenesis.
  • KHSRP serves as a prognostic marker for ESCC.
  • KHSRP represents a potential therapeutic target for ESCC treatment.
Keywords:
KHSRPRNA-binding proteinesophageal squamous cell carcinomamicroRNAoncogene

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