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Association between nonsteroidal anti-inflammatory drugs use and risk of central nervous system tumors: a

Tao Zhang1, Xiaowen Yang2, Pei Liu3

  • 1Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China.

Oncotarget
|December 20, 2017
PubMed

Insights

Nonsteroidal anti-inflammatory drugs (NSAIDs) use is linked to a reduced risk of central nervous system (CNS) tumors. This meta-analysis found that NSAIDs, including aspirin and non-aspirin types, may lower the risk of developing brain tumors.

Area of Science:

  • Oncology
  • Pharmacology
  • Epidemiology

Background:

  • The relationship between nonsteroidal anti-inflammatory drugs (NSAIDs) and central nervous system (CNS) tumor risk remains unclear despite previous investigations.
  • Existing studies present inconclusive findings regarding the protective effects of NSAIDs against CNS tumors.

Purpose of the Study:

  • To conduct a dose-response meta-analysis evaluating the association between NSAIDs consumption and the risk of developing CNS tumors.
  • To clarify the correlation between NSAIDs use and CNS tumor incidence.

Main Methods:

  • A meta-analysis was performed, incorporating data from 12 relevant studies published up to July 2017.
  • Dose-response relationships were analyzed to quantify the impact of NSAIDs usage patterns on CNS tumor risk.

Main Results:

  • NSAIDs use, encompassing both aspirin and non-aspirin formulations, demonstrated a significant association with a reduced risk of CNS tumors.
  • Specifically, NSAIDs use correlated with a lower risk of glioma and glioblastoma, but not meningioma.
  • A significant dose-response relationship was identified, with increased NSAIDs use (cumulative defined daily doses, prescriptions, or duration) correlating with decreased CNS tumor risk.

Conclusions:

  • NSAIDs consumption may play a beneficial role in mitigating the risk of CNS tumors.
  • Further large-scale studies with diverse ethnic populations are recommended to validate these findings and confirm the association.
Keywords:
central nervous system tumorsdose-response relationshipmeta analysisnonsteroidal anti-inflammatory drugs

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