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Published on: March 11, 2014
Study on expression of p16 and human papillomavirus 16 and 18 (E6) in OLP and its malignant transformation
Ting Liu1, Hong Zhang2, Xuesong Yang3
1College of Stomatology, Dalian Medical University, Dalian Medical University, Dalian, China; Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Objective:
The aim of this study is to investigate the expressions of p16 and HPV16/18(E6) in oral lichen planus (OLP) and malignant transformed OLP (MT-OLP).
Study Design:
The expression of p16 and HPV16/18(E6) in 40 cases of OLP and 6 MT-OLP was assessed by immunohistochemical staining. Twenty four cases of normal oral mucosa were used as controls.
Results:
Compared to normal oral mucosa, the expression of p16 and HPV16/18(E6) protein increased in OLP and MT-OLP. And there was a correlation between p16 expression and HPV infection in OLP and OLP malignant lesions (p < 0.0001).
Conclusions:
The expression of p16 protein might predict HPV16/18 infection in OLP. And HPV16/18(E6) infection might contribute to OLP malignant transformation.
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