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Paraoxonase-1 is a better indicator than HDL of Atherosclerosis - A pilot study in North Indian population
Kamna Singh1, Ritu Singh1, Sudhir Chandra1
1Department of Biochemistry, Lady Hardinge Medical College, New Delhi, 110001, India.
Objectives:
The present study aims to evaluate the levels of HDL and Paraoxonase-1 (PON1) and their correlation in atherosclerotic patients with and without diabetic mellitus (DM) as well as in control subjects in Northern Indian population.
Materials And Methods:
We analyzed lipid profiles and Serum PON1 levels by automated analyzer and ELISA, respectively. Study subjects (N = 150) were divided in three groups; Group I: Atherosclerotic patients without DM (N = 50), Group II: Atherosclerotic patients with DM (N = 50); Group III: Controls (N = 50).
Results:
We found a significantly (p < 0.0001) low levels of HDL-C in Group I (32.2 ± 7.3) and Group II (36.9 ± 11.5) as compared to Group III (41.0 ± 7.1). PON-1 levels were also significantly lower in Group I (60.1 ± 10.5) and Group II (50.0 ± 13.9) when compared to Group III (95.0 ± 12.0). We observed a significant correlation (r = 0.59, p < 0.001) between the levels of PON1 and HDL-C in study subjects.
Conclusions:
The reduced levels of HDL and PON-1 and their significant correlation in CAD patients may be associated with the pathogenesis of this disease. Considering HDL as a dependent variable, Paraoxonase-1 is the most important parameter contributing to the total variation in HDL in CAD.
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