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Human paraoxonase 2.

Sureerut Porntadavity1, Thinnakorn Permpongpaiboon2, Wanida Sukketsiri3

  • 1Department of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.

EXCLI Journal
|December 20, 2017
PubMed
Summary

Human paraoxonase 2 (PON2) is an intracellular protein protecting against oxidative stress and atherosclerosis. Emerging research links PON2 polymorphisms to cardiovascular disease (CVD), driving growing scientific interest.

Keywords:
antioxidantatherosclerosisoxidative stressparaoxonase 2

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Human paraoxonase 2 (PON2) is an intracellular protein with unique properties, distinct from PON1 and PON3.
  • PON2 is widely expressed, particularly in vital organs like the heart and lungs, functioning to reduce oxidative stress.

Purpose of the Study:

  • To review recent advancements in PON2 research.
  • To highlight PON2's role in preventing atherosclerosis and its association with cardiovascular disease (CVD).
  • To discuss the growing investigations into PON2 gene polymorphisms and CVD across diverse populations.

Main Methods:

  • Literature review of past and recent findings on PON2.
  • Analysis of PON2's intracellular functions and anti-oxidative mechanisms.
  • Examination of PON2's protective effects against atherosclerosis, including LDL oxidation and cholesterol metabolism.

Main Results:

  • PON2 demonstrates significant anti-atherosclerotic properties by preventing LDL oxidation and promoting cholesterol efflux.
  • Emerging evidence suggests PON2 is associated with cardiovascular disease (CVD).
  • Research on the link between common PON2 polymorphisms and CVD is rapidly expanding globally.

Conclusions:

  • PON2 plays a crucial role in cellular oxidative stress reduction and cardiovascular protection.
  • Further research into PON2 polymorphisms is warranted to understand their impact on CVD risk across different ethnic groups.