Related Experiment Video
Updated: Feb 16, 2026
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Novel biomarker SYT12 may contribute to predicting papillary thyroid cancer outcomes
J Jonklaas1,1, Srk Murthy2,2, D Liu3,3
1Division of Endocrinology, Georgetown University, Washington, DC 20007, USA.
Aim:
To investigate biomarkers for predicting papillary thyroid cancer outcomes.
Materials & Methods:
The expression of biomarkers (ITGA2, SYT12 and CDH3) was studied in a prospective cohort of patients with papillary thyroid cancer. Three outcomes of initial metastases, baseline status and longitudinal status were analyzed and correlated with the biomarkers.
Results:
SYT12 provided the best prediction of initial metastasis (sensitivity: 72%; specificity: 54%). SYT12 had the highest accuracy for predicting longitudinal status (sensitivity: 100%; specificity: 47%). The best performance for longitudinal status resulted from combining SYT12 with American Thyroid Association risk stratification, with sensitivity and specificity of 88 and 73%, respectively.
Conclusion:
SYT12 has some prognostic significance in papillary thyroid cancer. Further validation studies in larger populations are warranted.
