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Updated: Feb 16, 2026

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Hodgkin's Lymphoma in Crohn's Disease Treated with Infliximab
Diana Carvalho1, Pedro Russo1, Carlos Bernardes1
1Gastroenterology and Hepatology Department, Lisbon, Portugal.
Introduction:
Lymphoproliferative disorders, particularly non-Hodgkin's and Hodgkin's lymphomas, are rare in patients with inflammatory bowel diseases. The use of thiopurines and infection by Epstein-Barr virus are well-known cofactors that can raise its prevalence. Other risk factors such as disease activity and biological treatment are the subject of discussion, without enough data in the literature to confirm a potential association.
Methods:
We report a case of Hodgkin's lymphoma in a patient who had been treated with azathioprine and was on long-term monotherapy with infliximab.
Conclusions:
We stress the importance of recognizing the possible occurrence of a lymphoproliferative disorder in association with anti-tumor necrosis factor-α therapy.
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