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Drug discovery and development: Role of basic biological research
Richard C Mohs1, Nigel H Greig2
1Global Alzheimer's Platform Foundation, Washington, DC, USA.
Alzheimer'S & Dementia (New York, N. Y.)
|December 20, 2017
Summary
This article guides scientists in framing research for drug discovery and development, emphasizing the lengthy, complex process and the need for new tools to identify biological targets for new medicines.
Area of Science:
- Pharmacology
- Biomedical Research
- Translational Science
Background:
- Drug discovery and development is a lengthy, complex, and expensive undertaking.
- Numerous biological targets require investigation for each new medicine.
- Advancements in research tools are crucial for target identification and validation.
Purpose of the Study:
- To assist scientists in contextualizing their research within the drug discovery and development pipeline.
- To support the effective translation of preclinical findings into human therapies.
- To encourage submissions that address scientific and operational challenges in drug development.
Main Methods:
- Overview of the drug discovery and development process.
- Discussion of the challenges and complexities involved.
- Guidance on framing research reports for optimal impact.
Main Results:
- The process necessitates consideration of numerous biological targets.
- New research tools are often required for novel target investigation.
- Improving process efficiency can be achieved by addressing scientific and operational issues.
Conclusions:
- Framing research appropriately aids in the translation of preclinical findings.
- Understanding the drug development process enhances the opportunity for success.
- Further research addressing process challenges is encouraged.
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