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Updated: Jul 17, 2026

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
Published on: October 13, 2016
EU./U.S. CTAD Task Force on Alzheimer's Trial Populations
B Vellas1, C Sampaio, R Bateman
1Professor Bruno Vellas, MD, PhD, Hôpital Casselardit, Gerontopole, UMR INSERM1027, 170 Avenue Casselardit, 31059 Toulouse Cedex 03, France.
Selecting the right participants is crucial for Alzheimer's disease (AD) drug trials. Using advanced imaging like amyloid PET can improve trial accuracy by identifying patients with actual Alzheimer's pathology.
Area of Science:
- Neuroscience
- Clinical Trials
- Drug Development
Background:
- Alzheimer's disease (AD) trials often include patients without confirmed amyloid pathology.
- Dementia stages may be too advanced for disease-modifying therapies to be effective.
Purpose of the Study:
- To address challenges in screening and identifying participants for AD clinical trials.
- To improve the selection of study populations for effective drug development in dementia.
Main Methods:
- An international task force convened to discuss participant selection criteria.
- Focus on the impact of screening decisions on Alzheimer's disease drug development.
Main Results:
- Amyloid PET imaging reveals many participants in AD trials lack brain amyloidosis.
- Current trial populations may not be optimally targeted for disease-modifying interventions.
Conclusions:
- Accurate participant selection, guided by biomarkers like amyloid PET, is essential for successful AD therapeutics.
- Optimizing trial populations is critical for advancing drug development for Alzheimer's disease and other dementias.
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