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Hepatitis B virus reactivation in patients with rheumatoid arthritis: A single-center study

Toshihisa Matsuzaki¹, Katsumi Eguchi², Natsumi Nagao²

¹a Digestive Endoscopy Center, Sasebo Chuo Hospital , Nagasaki , Japan.

Modern Rheumatology

|December 20, 2017

Abstract

Objectives:

This study aimed to investigate the frequency of hepatitis B virus (HBV) reactivation in patients with rheumatoid arthritis (RA) and to verify the guidelines relating to HBV reactivation in Japan.

Methods:

We retrospectively investigated 1351 RA patients who were treated with antirheumatic drugs at our hospital.

Results:

Fifty patients (3.7%; 50/1351) were determined to be HBV carriers and 360 patients (26.7%; 360/1351) had resolved infections. HBV reactivation occurred in six cases (1.7%: 6/360) with resolved infections, of whom, two cases (0.6%; 2/360) developed de novo HBV infections. Eleven of the patients who were HBV carriers received a nucleoside analogue (NA) prophylactically. In all of the cases, the HBV-DNA levels became undetectable and the patients' liver function normalized. Sixteen patients, who had lower titers of the HBV surface antigen and undetectable HBV-DNA levels, did not show HBV reactivation in the absence of NA therapy.

Conclusions:

The results from this study suggest that HBV reactivation might not be so frequent among RA patients, and that reliable indicators for prescribing a NA should be clarified for RA patients.

Keywords:

De novo hepatitis B disease-modifying antirheumatic drugs hepatitis B virus reactivation nucleoside analogue rheumatoid arthritis

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