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Updated: Feb 16, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Weakly Coordinating, Ketone-Directed Cp*Co(III)-Catalyzed C-H Allylation on Arenes and Indoles
Md Raja Sk1, Sourav Sekhar Bera1, Modhu Sudan Maji1
1Department of Chemistry, Indian Institute of Technology Kharagpur , Kharagpur 721302, W. B., India.
Abstract:
Weakly coordinating, ketone-directed, regioselective monoallylation of arenes and indoles is reported using a stable and cost-effective high-valent cobalt(III)-catalyst to access several important molecular building blocks. The allylation proceeds smoothly with a variety of substrates in the presence of various electron-rich and -deficient substituents. The method was applied to the formal synthesis of an ancisheynine alkaloid, a highly conjugated azatetracene, and isochroman. The mechanistic study reveals that the allylation reaction follows a base-assisted intermolecular electrophilic substitution pathway.
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