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Updated: Feb 16, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
The development of stimuli-responsive polymeric micelles for effective delivery of chemotherapeutic agents
Yimu Li1, Aihua Yu1, Lingbing Li1
1a Department of Pharmaceutics, College of Pharmacy , Shandong University , Jinan , PR China.
Abstract:
Stimuli-responsive polymeric micelles, a novel category of polymeric micelles with response to endogenous or exogenous environments, show variable physicochemical properties as the variation of endogenous or exogenous circumstances. Because of differences between tumour tissues and normal tissues in physicochemical properties and sensitivity to variation of endogenous or exogenous environments, the application of chemotherapeutic agents loaded stimuli-responsive polymeric micelles are regarded as promising strategies for tumour treatment. In this article, the recent developments of chemotherapeutic agents loaded stimuli-responsive polymeric micelles, for example the preparation of novel stimuli-responsive polymeric micelles and the research progresses of action mechanisms of chemotherapeutic agents loaded micelles, were reviewed and discussed in detail. The advantages of stimuli-responsive chemotherapeutic agents loaded polymeric micelles in practical tumour treatment were also illustrated with the assistance of examples of stimuli-responsive polymeric micelles for antitumor agents delivery.
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