Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The surgical margin in soft-tissue sarcoma.

R S Bell1, B O'Sullivan, F F Liu

  • 1Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada.

The Journal of Bone and Joint Surgery. American Volume
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Jejunal undifferentiated carcinoma with multiple metastases involving the right palatine tonsil: a case report].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2026
Same author

[Epidemiological characteristics of typhoid fever and paratyphoid fever outbreaks in China from 2008 to 2024].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[Efficiency and safety of JAK inhibitors for alopecia totalis and alopecia universalis].

Zhonghua yi xue za zhi·2025
Same author

[Genomic profiles of primary and acquired MET mutations in NSCLC and the impact of co-mutations on treatment outcomes].

Zhonghua yi xue za zhi·2025
Same author

International guidelines for the delineation of the postoperative clinical target volumes (CTV) for parotid and submandibular gland cancers.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025
Same author

Dynamic prediction of Radiotherapy toxicities in Head and neck cancer using clinical and imaging data.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025
Same journal

Do Younger Patients Undergoing Transfibular Total Ankle Arthroplasty Achieve Outcomes Comparable with Those of Older Patients? Interpreting Nonsignificant Differences in Clinical Research: Commentary on an article by Kevin A. Schafer, MD, et al.: "Clinical and Radiographic Outcomes at a Mean of 7 Years Following Primary Transfibular Total Ankle Arthroplasty in Younger and Older Patients".

The Journal of bone and joint surgery. American volume·2026
Same journal

Clinical and Radiographic Outcomes at a Mean of 7 Years Following Primary Transfibular Total Ankle Arthroplasty in Younger and Older Patients.

The Journal of bone and joint surgery. American volume·2026
Same journal

Quantifying Protrusio Risk in the Metastatic Acetabulum: A Step Toward Precision: Commentary on an article by Will Jiang, BS, et al.: "Development of a Radiographic Scoring System to Estimate Acetabular Protrusion Risk in Patients with Osteolytic Periacetabular Metastases".

The Journal of bone and joint surgery. American volume·2026
Same journal

Can We Find the Oracle of Fracture Union?: Commentary on an article by Luke A. Lopas, MD, et al.: "A Fracture Healing Odyssey: Kinematic Comparison of Unions and Nonunions in Human Lower-Extremity Long Bones Treated with Intramedullary Nailing. A Retrospective Cohort Study".

The Journal of bone and joint surgery. American volume·2026
Same journal

Stacked-Cone Constructs for Extensive Tibial and/or Femoral Bone Loss in Complex Primary and Revision TKA: A Multicenter Analysis of 84 Cases.

The Journal of bone and joint surgery. American volume·2026
Same journal

Shaping Modern Practice in South Korea: A Centennial Review of Orthopaedics at Severance Hospital and Yonsei University College of Medicine.

The Journal of bone and joint surgery. American volume·2026
See all related articles

Adequate surgical margins are crucial for preventing local recurrence in extremity soft-tissue sarcomas. Tumor size significantly impacts the risk of systemic disease spread in patients treated with resection and radiation therapy.

Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Soft-tissue sarcomas in extremities require effective treatment strategies.
  • Local resection and adjuvant radiation therapy are common treatment modalities.

Purpose of the Study:

  • To identify prognostic factors for local recurrence and systemic disease in extremity soft-tissue sarcomas.
  • To evaluate the impact of surgical margins and tumor characteristics on outcomes.

Main Methods:

  • Retrospective review of 100 patients with extremity soft-tissue sarcoma treated with local resection and adjuvant radiation.
  • Data collected included patient demographics, tumor characteristics (size, grade, depth, compartmental status), chemotherapy, and radiation dose.
  • Cox multivariate analysis was used to assess variables associated with local recurrence and systemic disease.

Related Experiment Videos

Main Results:

  • Adequacy of surgical margins was the sole significant predictor of local relapse (p = 0.0004).
  • Tumor size was the primary determinant of systemic disease risk (p = 0.0008).

Conclusions:

  • Achieving adequate surgical margins is critical for local control of extremity soft-tissue sarcomas.
  • Tumor size is a key factor in predicting the risk of distant metastasis.