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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
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Nanoparticles of metal-organic cages designed to encapsulate platinum-based anticancer agents
Zhizhou Yue1, Han Wang, David J Bowers
1Department of Chemistry and Biochemistry, Kent State University, 224 Williams Hall, Kent, Ohio 44242, USA. yzheng7@kent.edu.
Dalton Transactions (Cambridge, England : 2003)
|December 20, 2017
Abstract:
We present a novel design to use metal-organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(iv) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host-guest interactions, which then forms drug-loaded nanoparticles with an anionic polymer.
