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Autophagy: A new treatment strategy for MSC-based therapy in acute kidney injury (Review)

Haoyuan Jia1, Yongmin Yan1, Zhaofeng Liang1

  • 1Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

Molecular Medicine Reports
|December 20, 2017
PubMed

Insights

Acute kidney injury (AKI) involves autophagy in kidney cells. Mesenchymal stem cell therapy shows promise for treating AKI, offering potential for improved patient outcomes.

Area of Science:

  • Nephrology
  • Cell Biology
  • Regenerative Medicine

Background:

  • Acute kidney injury (AKI) is a prevalent clinical condition linked to adverse health outcomes.
  • Autophagy, a fundamental cellular process, plays a critical role in various biological functions and diseases.
  • Recent evidence indicates autophagy is activated in proximal tubular cells during AKI.

Purpose of the Study:

  • To review the current understanding of autophagy's role in AKI.
  • To explore the therapeutic potential of mesenchymal stem cells (MSCs) for AKI treatment.
  • To highlight recent advancements in AKI research.

Main Methods:

  • Literature review of recent studies on autophagy and AKI.
  • Analysis of research on MSC-based therapies for renal injury.
  • Synthesis of findings regarding autophagy's dual role (pro-survival/pro-death) in AKI.

Main Results:

  • Autophagy is demonstrably induced in proximal tubular cells during AKI.
  • Mesenchymal stem cells exhibit therapeutic potential in repairing renal damage.
  • Autophagy's specific role in AKI can be context-dependent, acting as either a survival or death mechanism.

Conclusions:

  • Autophagy is a key player in the pathophysiology of AKI.
  • MSC-based therapies represent a promising avenue for AKI treatment.
  • Further investigation is crucial for developing effective AKI prevention and treatment strategies.
Keywords:
autophagyacute kidney injurymesenchymal stem cellscell death

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