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Updated: Feb 16, 2026

Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica
Published on: August 31, 2011
Unconventional Functions of Muscles in Planarian Regeneration
Stephen Cutie1, Alison T Hoang1, Alexander Y Payumo1
1Cardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94158, USA.
Abstract:
Muscles are traditionally considered in the context of force generation. Scimone et al. (2017), reporting in Nature, now examine muscles in a developmental setting and find unexpected roles for distinct planarian muscle fibers. The authors show that muscles provide patterning signals to promote regeneration and guide tissue growth after injury.
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