Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 16, 2026

Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration
10:22

Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration

Published on: June 25, 2015

11.1K

Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs.

Subhra P Hui1, Delicia Z Sheng1, Kotaro Sugimoto1

  • 1Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.

Developmental Cell
|December 20, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Examining selection dynamics and limitations in multi-round protein selection of high diversity libraries.

Protein engineering, design & selection : PEDS·2026
Same author

Hypoxia-activated <i>scleraxis a</i> mediates epicardial progenitor differentiation into a unique cardiac perivascular cell type.

bioRxiv : the preprint server for biology·2026
Same author

Identification of ovarian cancer-associated antigens forming complexes with autoantibodies.

Journal of ovarian research·2026
Same author

Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis.

Nature communications·2026
Same author

Autopsy detection of Pneumatosis Cystoides Intestinalis in a patient with end-stage renal failure from autosomal dominant polycystic kidney disease undergoing dialysis: a case report.

Oxford medical case reports·2025

Zebrafish regulatory T-like (zTreg) cells promote organ regeneration by secreting specific factors. Depleting these cells impairs precursor proliferation and regeneration, highlighting their therapeutic potential.

Area of Science:

  • Regenerative Medicine
  • Immunology
  • Developmental Biology

Background:

  • Humans exhibit limited organ regeneration compared to species like zebrafish.
  • Understanding the mechanisms of robust regeneration in zebrafish can inform human therapies.

Purpose of the Study:

  • To investigate the role of zebrafish regulatory T-like (zTreg) cells in organ regeneration.
  • To identify the mechanisms by which zTreg cells promote tissue repair.

Main Methods:

  • Utilized established models for spinal cord, heart, and retina regeneration in zebrafish.
  • Employed conditional ablation techniques to deplete zTreg cells.
  • Analyzed the effects of zTreg cell depletion on precursor cell proliferation and organ regeneration.
  • Investigated the role of secreted factors and inflammation modulation by zTreg cells.
Keywords:
cardiomyocyteheartneural stem cellregenerationregulatory T cellretinaspinal cordzebrafish

More Related Videos

Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration
06:08

Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration

Published on: July 5, 2024

1.7K
Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish
09:39

Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish

Published on: December 26, 2014

11.3K

Related Experiment Videos

Last Updated: Feb 16, 2026

Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration
10:22

Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration

Published on: June 25, 2015

11.1K
Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration
06:08

Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration

Published on: July 5, 2024

1.7K
Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish
09:39

Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish

Published on: December 26, 2014

11.3K

Main Results:

  • zTreg cells rapidly migrated to damaged organs (spinal cord, heart, retina).
  • Conditional ablation of zTreg cells inhibited organ regeneration by impairing precursor cell proliferation.
  • zTreg cells secreted organ-specific regenerative factors (Ntf3, Nrg1, Igf1) independently of interleukin-10.
  • Recombinant regeneration factors rescued defects caused by zTreg cell depletion.

Conclusions:

  • zTreg cells play a crucial, organ-specific role in maintaining pro-regenerative capacity.
  • zTreg cells stimulate regeneration via secreted factors, not solely through inflammation modulation.
  • These findings suggest potential therapeutic strategies for regenerative medicine by harnessing zTreg cell functions.