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Preclinical Imaging for the Study of Mouse Models of Thyroid Cancer
Adelaide Greco1,2,3, Luigi Auletta4, Francesca Maria Orlandella5
1Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy. adegreco@unina.it.
Abstract:
Thyroid cancer, which represents the most common tumors among endocrine malignancies, comprises a wide range of neoplasms with different clinical aggressiveness. One of the most important challenges in research is to identify mouse models that most closely resemble human pathology; other goals include finding a way to detect markers of disease that common to humans and mice and to identify the most appropriate and least invasive therapeutic strategies for specific tumor types. Preclinical thyroid imaging includes a wide range of techniques that allow for morphological and functional characterization of thyroid disease as well as targeting and in most cases, this imaging allows quantitative analysis of the molecular pattern of the thyroid cancer. The aim of this review paper is to provide an overview of all of the imaging techniques used to date both for diagnosis and theranostic purposes in mouse models of thyroid cancer.
Insights
This review explores preclinical thyroid imaging techniques for mouse models of thyroid cancer. It highlights methods for diagnosis and theranostics, aiding research into this common endocrine malignancy.
Area of Science:
- Endocrinology
- Oncology
- Medical Imaging
Background:
- Thyroid cancer is the most common endocrine malignancy, presenting diverse clinical behaviors.
- Developing accurate mouse models is crucial for understanding human thyroid pathology.
- Identifying common biomarkers and effective, minimally invasive therapies remains a key research challenge.
Purpose of the Study:
- To review diagnostic and theranostic imaging techniques in preclinical mouse models of thyroid cancer.
- To provide a comprehensive overview of current imaging modalities for thyroid cancer research.
- To discuss the role of imaging in characterizing thyroid cancer in mouse models.
Main Methods:
- Literature review of preclinical thyroid imaging techniques.
- Analysis of imaging modalities used for morphological and functional characterization.
- Evaluation of techniques for molecular pattern analysis and theranostic applications.
Main Results:
- Preclinical thyroid imaging offers detailed morphological and functional insights.
- Various imaging techniques enable quantitative analysis of thyroid cancer molecular patterns.
- Imaging facilitates both diagnosis and theranostic applications in mouse models.
Conclusions:
- Imaging techniques are vital for characterizing thyroid cancer in mouse models.
- These methods support the development of targeted therapies and diagnostic markers.
- A comprehensive understanding of imaging modalities is essential for advancing thyroid cancer research.
