Oligofructose Provides Laxation for Irregularity Associated with Low Fiber Intake

Area of Science:

• Nutrition Science
• Gastroenterology
• Microbiome Research

Background:

• Inadequate dietary fiber intake is a major cause of constipation in Western populations.
• While fiber supplements are common, their efficacy varies by fiber type.
• Oligofructose is a prebiotic fiber known for its potential health benefits.

Purpose of the Study:

• To evaluate the laxation benefits of oligofructose supplementation in adults with low dietary fiber intake and constipation.
• To compare the effects of different doses of oligofructose against a maltodextrin placebo.
• To assess the impact on stool frequency, consistency, and gastrointestinal sensations.

Main Methods:

• A randomized controlled trial with healthy adults experiencing constipation (≤3 bowel movements/week) and low fiber intake.
• Participants received either oligofructose (OF) or maltodextrin (MD) placebo.
• OF dosage was escalated from 5g to 15g daily over four-week periods.

Main Results:

• Oligofructose significantly increased stool frequency compared to placebo, particularly at 15 g/day (p=0.023).
• Benefits were more pronounced in individuals with higher habitual fiber intake (>13 g/day).
• No significant changes in stool consistency or increased gastrointestinal distress were observed.

Conclusions:

• Daily oligofructose supplementation effectively improves laxation in individuals with constipation due to low fiber intake.
• Oligofructose acts as a beneficial prebiotic fiber, enhancing bowel regularity without adverse GI effects.
• This study supports oligofructose as a safe and effective dietary supplement for managing constipation.