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Lipid-coated calcium phosphate nanoparticle and beyond: a versatile platform for drug delivery
Jia-Lin Huang1,2, Hong-Zhuan Chen1, Xiao-Ling Gao1
1a Department of Pharmacology and Chemical Biology, Faculty of Basic Medicine , Shanghai Jiao Tong University School of Medicine , Shanghai , PR China.
Abstract:
In recent years, lipid-coated calcium-phosphate (LCP) nanoparticle has been developed as a versatile platform for delivery of various therapeutics including gene, protein/peptide, chemotherapeutics and theranostic agents. The high endosomal escape, coupled with the ability to efficiently encapsulate phosphorylated drugs or prodrugs, make LCP become attractive vehicle for drug delivery. Additionally, the principle behind LCP formulation has also allowed rational design of LCP-derived nanoparticles (NPs) with other solid core or lipid membrane to overcome the various drug delivery barriers. Here, we briefly review the history of the development of LCP NPs, highlight the optimisations and modulations in the development process, and summarise the major applications of LCP NPs and LCP-derived NPs in drug delivery.
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