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Related Experiment Video

Updated: Feb 16, 2026

Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples
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Neutrophil elastase in bronchiectasis.

Andrea Gramegna1, Francesco Amati1, Leonardo Terranova2

  • 1Department of Pathophysiology and Transplantation, University of Milan, Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Respiratory Research
|December 21, 2017
PubMed
Summary
This summary is machine-generated.

Neutrophil elastase (NE) is a useful inflammatory marker in bronchiectasis, predicting exacerbations and mortality. Further research is needed to evaluate NE inhibitors as a potential treatment for this condition.

Keywords:
BronchiectasisDesmosineNeutrophil elastaseNeutrophil elastase inhibitorsProtease

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Area of Science:

  • Pulmonology
  • Inflammation Research
  • Medical Biochemistry

Background:

  • The role of neutrophil elastase (NE) in bronchiectasis is not well-defined, with limited preclinical data.
  • Current understanding relies heavily on data from cystic fibrosis (CF), where NE is a predictor of outcomes and a treatment target.

Purpose of the Study:

  • To systematically review existing scientific evidence to better evaluate the role of NE in bronchiectasis.
  • To assess NE as an inflammatory marker and a potential therapeutic target in bronchiectasis.

Main Methods:

  • A systematic literature search was conducted on PubMed up to May 15, 2017.
  • Two independent investigators selected studies based on predefined criteria.
  • Data from 31 studies involving 2679 patients were extracted and analyzed.

Main Results:

  • Sputum NE is a valuable inflammatory marker in stable bronchiectasis and during exacerbations.
  • NE levels correlate with the risk of exacerbations, time to the next exacerbation, and all-cause mortality.
  • NE is associated with treatment responses, including antibiotic therapy.

Conclusions:

  • Neutrophil elastase serves as a significant inflammatory marker in bronchiectasis.
  • NE inhibition is in early developmental stages, requiring further interventional studies for safety and efficacy evaluation.
  • Targeting NE may offer a future therapeutic strategy for bronchiectasis management.