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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Perimenopausal bone histomorphometry before and after menopause.

Robert R Recker1, Joan M Lappe1, Michael Davies2

  • 1Creighton University School of Medicine, 6829 N 72nd St, Ste 7400, Omaha, NE, 68122, United States.

Bone
|December 21, 2017
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Summary
This summary is machine-generated.

Healthy menopause significantly increases bone remodeling and decreases bone density. This study provides crucial bone histomorphometry data for pre- and postmenopausal women, aiding clinical and research understanding of menopausal bone changes.

Keywords:
BiopsyBoneHistomorphometryMenopauseNormalsTransiliac

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Area of Science:

  • Bone biology and metabolism
  • Menopause research
  • Skeletal health

Background:

  • Limited normal bone histomorphometry data exists for comparison in clinical and research settings.
  • Understanding menopausal bone changes is crucial for skeletal health management.

Purpose of the Study:

  • To provide static and dynamic bone histomorphometry data from healthy premenopausal women.
  • To present paired bone histomorphometry data from healthy women before and after menopause.
  • To establish a normative dataset for bone histomorphometry in healthy aging women.

Main Methods:

  • Transiliac bone biopsies performed on 76 healthy premenopausal women (age >46).
  • Repeat biopsies on 51 women 12 months after their last menses.
  • Bone biopsies analyzed for static and dynamic histomorphometry following tetracycline labeling.
  • Serum biochemical markers and serial DXA scans collected during a 9.5-year observation period.

Main Results:

  • Bone remodeling doubled postmenopause, with increased serum bone markers.
  • Lumbar spine bone density declined significantly after menopause.
  • Significant correlations observed between serum bone markers and histomorphometry variables.

Conclusions:

  • Healthy menopause is associated with a substantial increase in bone remodeling and a loss of bone density.
  • The findings provide valuable normative data for bone histomorphometry across menopause.
  • Further research is needed to elucidate the mechanisms behind these transmenopausal skeletal changes.