Related Experiment Video

Updated: Feb 16, 2026

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
09:58

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

14.9K

The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection

N Gorlé1, C Blaecher2, E Bauwens2

  • 1VIB Center for Inflammation Research, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium.

Brain, Behavior, and Immunity
|December 21, 2017
PubMed

Insights

Helicobacter suis infection causes brain inflammation and cognitive decline in mice. This stomach bacterium disrupts the blood-cerebrospinal fluid barrier, impacting brain health.

Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • Gut microbiota shifts are linked to neurological disorders.
  • Helicobacter suis (H. suis) shows high prevalence in Parkinson's disease patients.
  • The stomach-brain axis and its role in neurological conditions require further investigation.

Purpose of the Study:

  • To investigate the impact of gastric H. suis infection on the brain in a mouse model.
  • To explore the mechanisms by which H. suis influences brain inflammation and cognitive function.
  • To identify the role of the choroid plexus in the stomach-brain axis.

Main Methods:

  • Mice were infected with H. suis for one month.
  • Brain inflammation markers (microglia activation) and cognitive function were assessed.
  • Blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier integrity were evaluated.
  • Gastrointestinal barrier function and systemic inflammation were analyzed.

Main Results:

  • H. suis infection led to increased brain inflammation and cognitive decline in mice.
  • Choroid plexus inflammation and disruption of the epithelial blood-CSF barrier were observed.
  • The endothelial blood-brain barrier remained intact.
  • Increased gastrointestinal permeability and low-grade systemic inflammation accompanied the infection.

Conclusions:

  • H. suis infection induces brain inflammation and cognitive decline.
  • The choroid plexus plays a significant role in the stomach-brain axis.
  • H. suis-induced gut permeability and peripheral inflammation impact brain homeostasis via the blood-CSF barrier.
Keywords:
Blood-brain barrierChoroid plexusGut-brain axisHelicobacterStomach-brain axis

More Related Videos

Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies04:25

Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies

Published on: December 15, 2023

3.9K
Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography03:47

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography

Published on: November 1, 2024

422

Related Concept Videos

Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
2.5K
Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
1.3K
Stomach pH Regulation01:21

Stomach pH Regulation

The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
7.3K
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.4K
Stomach Histology01:26

Stomach Histology

The stomach comprises several layers that work together to facilitate digestion and protect the organ. The outermost layer is called the serosa, which provides support and protection to the stomach. The muscularis externa layer is responsible for the mechanical breakdown of food by contracting and moving the stomach. The submucosa layer, located beneath the muscularis externa, contains connective tissue, blood vessels, nerves, and glands that secrete mucus and other substances essential for...
3.3K
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.5K