Related Experiment Video
Updated: Feb 16, 2026
The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice
Published on: September 19, 2019
Research progress on 5hmC and TET dioxygenases in neurodevelopment and neurological diseases
Jian Wang1, Kai Xiang Zhang1, Guo Zhen Lu1
1Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China.
Abstract:
The development of the nervous system is coordinately regulated by multiple interacting factors. If a certain factor is altered or mutated, the coordinated developmental processes could be disrupted, resulting in neurological diseases. The 5-hydroxymethylcytosine (5hmC) is an intermediate product of the DNA demethylation processes. 5hmC and its metabolic enzymes, the ten-eleven translocation protein-TET family of dioxygenases, have recently been identified as new epigenetic players important in the regulation of the nervous system development, as well as in cognition, memory and other neurological functions. In various studies on neurodevelopment and neurodegeneration related diseases, the levels of 5hmC and TET proteins could be differentially regulated during development and/or disease pathogenesis, suggesting the potentially critical roles of 5hmC and TETs in these neural developmental and disease processes. In this review, we summarize the recent advances in research on 5hmC and TET dioxygenases in the regulation of neurodevelopment and neurological diseases, thereby providing significant insights on the involvements of 5hmC and TETs in neurodevelopment and on establishing new therapeutic strategies for human neurological diseases.
Insights
The ten-eleven translocation (TET) enzymes and 5-hydroxymethylcytosine (5hmC) are crucial epigenetic regulators in nervous system development. Dysregulation of 5hmC and TETs is linked to neurological diseases, offering potential therapeutic targets.
Area of Science:
- Epigenetics
- Neuroscience
- Molecular Biology
Background:
- Nervous system development relies on complex interactions; disruptions can cause neurological diseases.
- 5-hydroxymethylcytosine (5hmC) is a key intermediate in DNA demethylation.
- The ten-eleven translocation (TET) family of dioxygenases metabolizes 5hmC.
Purpose of the Study:
- To review recent research on 5hmC and TET dioxygenases in neurodevelopment.
- To explore their roles in neurological diseases.
- To provide insights for new therapeutic strategies.
Main Methods:
- Literature review of studies on 5hmC and TETs in neurodevelopment and neurological diseases.
- Analysis of differential regulation of 5hmC and TETs during neural development and disease.
- Synthesis of current understanding of their epigenetic regulatory mechanisms.
Main Results:
- 5hmC and TET proteins are identified as critical epigenetic regulators in the nervous system.
- Altered levels of 5hmC and TETs are observed in neurodevelopmental and neurodegenerative diseases.
- These epigenetic factors play significant roles in cognition and memory.
Conclusions:
- 5hmC and TETs are vital for normal neurodevelopment and function.
- Their dysregulation contributes to neurological disorders.
- Targeting 5hmC and TET pathways may offer novel therapeutic avenues for neurological diseases.
More Related Videos
10:33Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
Published on: October 15, 2018
09:02Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
Published on: June 9, 2017
