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Tenascin-C Promotes Tumor Cell Migration and Metastasis through Integrin α9β1-Mediated YAP Inhibition

Zhen Sun1,2,3,4, Anja Schwenzer1,2,3,4, Tristan Rupp1,2,3,4

  • 1INSERM U1109 - MN3T, The Microenvironmental Niche in Tumorigenesis and Targeted Therapy, Hôpital Civil, Institut d'Hématologie et d'Immunologie, Strasbourg, France.

Cancer Research
|December 21, 2017
PubMed
Summary

Tenascin-C promotes cancer metastasis by activating integrin α9β1, which inhibits YAP signaling. This mechanism explains how tenascin-C drives tumor cell migration and progression in the tumor microenvironment.

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