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The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
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When E-cadherin is away, centrosomes can play.

Diana Vargas-Hurtado1, Renata Basto2

  • 1Institut Curie, Paris Sciences et Lettres Research University, CNRS UMR144, Paris, France.

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Cancer cells with extra centrosomes cluster to prevent abnormal cell division. This study reveals a connection between this clustering ability and cell cortex contractility, mediated by E-cadherin and DDR1.

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Area of Science:

  • Cell Biology
  • Cancer Biology
  • Biophysics

Background:

  • Centrosome clustering is a mechanism cancer cells use to manage supernumerary centrosomes, preventing multipolar cell divisions.
  • The cell-intrinsic factors governing centrosome clustering remain incompletely understood.

Purpose of the Study:

  • To investigate the relationship between cell-intrinsic properties and the capacity for centrosome clustering in cancer cells.
  • To identify novel molecular players involved in regulating centrosome clustering.

Main Methods:

  • The study likely involved cell culture experiments observing centrosome dynamics.
  • Investigated the roles of E-cadherin and DDR1 in centrosome clustering.
  • Assessed the impact of cortical contractility on centrosome clustering capacity.

Main Results:

  • An unexpected link was discovered between the ability of cells to cluster centrosomes and their cortical contractility.
  • E-cadherin and DDR1 were identified as key proteins mediating this connection.

Conclusions:

  • Cortical contractility, influenced by E-cadherin and DDR1, plays a significant role in centrosome clustering.
  • This finding provides new insights into how cancer cells manage supernumerary centrosomes and maintain genomic stability.