Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

1.2K
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.2K
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

369
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
369
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

1.6K
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
1.6K
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

1.0K
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.0K
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

984
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
984
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

1.8K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incorporating Teamwork Strategies for Internal Medicine Residents in Training to Mitigate Hospital Utilization for High-Risk Patients.

Rhode Island medical journal (2013)·2026
Same author

Discovery of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 Main Protease through Computer-Aided Drug Design.

Journal of medicinal chemistry·2025
Same author

Physical Activity Counseling Education: The Use of Theory in Development, Implementation, and Evaluation.

The Journal of continuing education in the health professions·2025
Same author

Coefficients in Taylor's law increase with the time scale of water clarity measurements in a global suite of lakes.

Ecology letters·2024
Same author

The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading.

Molecular cancer therapeutics·2024
Same author

Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1.

Journal of medicinal chemistry·2024

Related Experiment Video

Updated: Feb 16, 2026

Measurement of Heart Contractility in Isolated Adult Human Primary Cardiomyocytes
09:17

Measurement of Heart Contractility in Isolated Adult Human Primary Cardiomyocytes

Published on: August 9, 2022

2.6K

Correction to "Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure".

Marion Lanier, Jason Pickens, Simone V Bigi

    ACS Medicinal Chemistry Letters
    |December 21, 2017
    PubMed
    Summary

    This study corrects a previously published article DOI. The correction ensures accurate citation and referencing for future scientific research and discovery.

    More Related Videos

    Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
    05:08

    Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

    Published on: October 3, 2019

    11.9K
    Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
    09:20

    Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

    Published on: February 13, 2021

    7.1K

    Related Experiment Videos

    Last Updated: Feb 16, 2026

    Measurement of Heart Contractility in Isolated Adult Human Primary Cardiomyocytes
    09:17

    Measurement of Heart Contractility in Isolated Adult Human Primary Cardiomyocytes

    Published on: August 9, 2022

    2.6K
    Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
    05:08

    Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

    Published on: October 3, 2019

    11.9K
    Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
    09:20

    Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

    Published on: February 13, 2021

    7.1K

    Area of Science:

    • Scientific Publishing
    • Scholarly Communication

    Background:

    • A previous article DOI requires correction.
    • Accurate citation is crucial in scientific literature.

    Purpose of the Study:

    • To provide the correct article DOI.
    • To ensure the integrity of scientific records.

    Main Methods:

    • Identifying the incorrect DOI.
    • Issuing a correction notice.

    Main Results:

    • The correct article DOI has been provided.
    • This facilitates proper referencing.

    Conclusions:

    • The correction ensures the accuracy of the scientific record.
    • Proper citation is vital for reproducible research.